Chin. J. Org. Chem. ›› 2015, Vol. 35 ›› Issue (12): 2610-2616.DOI: 10.6023/cjoc201508015 Previous Articles     Next Articles



戴红a, 葛书山a, 戴宝江b, 李钰a, 施磊a, 李阳a, 方源a, 石玉军a   

  1. a 南通大学化学化工学院 南通 226019;
    b 南通职业大学化学与生物工程学院 南通 226007
  • 收稿日期:2015-08-14 修回日期:2015-09-23 发布日期:2015-10-08
  • 通讯作者: 施磊, 石玉军;
  • 基金资助:

    国家自然科学基金(Nos. 21202089, 21372135)和南通市科技计划(Nos. AS2013002, AS2014011)资助项目.

Synthesis and Biological Activity of Novel 1,1-Dichloropropene Derivatives Containing N-Heterocycles

Dai Honga, Ge Shushana, Dai Baojiangb, Li Yua, Shi Leia, Li Yanga, Fang Yuana, Shi Yujuna   

  1. a College of Chemistry and Chemical Engineering, Nantong University, Nantong 226019;
    b School of Chemical and Biological Engineering, Nantong Vocational University, Nantong 226007
  • Received:2015-08-14 Revised:2015-09-23 Published:2015-10-08
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos. 21202089, 21372135), and the Science and Technology Project Fund of Nantong City (Nos. AS2013002, AS2014011).

In search of novel 1,1-dichloropropene compounds with potent bioactivities, a series of novel 1,1-dichloropropene derivatives containing N-heterocycles were synthesized by the strategy of active substructure combination. The structures of the target compounds were confirmed by 1H NMR, 13C NMR and elemental analysis. Preliminary bioassay indicated that most of the title compounds showed good larvicidal activity against Oriental armyworm at the concentration of 500 μg/mL. For example, the inhibition rates against Oriental armyworm of compounds 6a, 6b, 6c, 6d, 6e, 6f, 6i, 6l, 6m and 6o were all 100%. Besides, some target compounds displayed certain insecticidal activity against Aphis craccivora at the concentration of 500 μg/mL.

Key words: N-heterocycle, 1,1-dichloropropene, synthesis, bioactivity