Chin. J. Org. Chem. ›› 2016, Vol. 36 ›› Issue (5): 927-938.DOI: 10.6023/cjoc201511024 Previous Articles     Next Articles



刘玉婷, 吴倩倩, 尹大伟, 李荻扬   

  1. 陕西科技大学化学与化工学院 教育部轻化工助剂化学与技术重点实验室 西安 710021
  • 收稿日期:2015-11-13 修回日期:2015-12-15 发布日期:2016-01-15
  • 通讯作者: 刘玉婷
  • 基金资助:


Latest Progress and Application of Mannich Reaction

Liu Yuting, Wu Qianqian, Yin Dawei, Li Diyang   

  1. Key Laboratory of Auxiliary Chemistry & Technology for Chemical Industry, Ministry of Education, College of Chemistry and Chemical Engineering, Shaanxi University of Science & Technology, Xi'an 710021
  • Received:2015-11-13 Revised:2015-12-15 Published:2016-01-15
  • Supported by:

    Project supported by the Key Laboratory Project of Shaanxi Provincial Department of Education (No. 13J017) and the Preliminary Projects of National Basic Research Program of China (973 Program) (No. 2014CB260411).

Mannich reaction is very important in organic chemistry, especially plays a very important role in the synthesis of drugs. In addition, Mannich base has widespread attention because of it is more significant and specific biological activity. Mannich reaction, diastereoselectivity Mannich reaction, enantioselective Mannich reaction and the application of Mannich reaction are introduced. Finally, the development aspect of this research is brought forward.

Key words: Mannich reaction, Mannich base, catalyst, application, diastereoselectivity, enantioselective