Chin. J. Org. Chem. ›› 2017, Vol. 37 ›› Issue (2): 508-513.DOI: 10.6023/cjoc201608017 Previous Articles     Next Articles



林伟a, 郑永祥b, 黄志斌b, 史达清b   

  1. a 江苏理工学院化学与环境工程学院 常州 213001;
    b 苏州大学材料与化学化工学部 苏州 215123
  • 收稿日期:2016-08-22 修回日期:2016-11-02 发布日期:2016-11-17
  • 通讯作者: 史达清
  • 基金资助:


Rapid and Efficient Ultrasound-Assisted Method for the Synthesis of 2-Thioxo-2H-thiopyran and 2-Amino-6-thioxodihydropyridine Derivatives

Lin Weia, Zheng Yongxiangb, Huang Zhibinb, Shi Daqingb   

  1. a School of Chemistry and Environmental Engineering, Jiangsu Technology of University, Changzhou 213001;
    b College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123
  • Received:2016-08-22 Revised:2016-11-02 Published:2016-11-17
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 21502074) and the Major Basic Research Project of the Natural Science Foundation of the Jiangsu Higher Education Institutions (No. 15KJA150006).

A rapid and efficient ultrasound-assisted method for the synthesis of 2-thioxo-2H-thiopyran and 2-amino-6-thioxodihydropyridine derivatives by the reaction of 2-(1-phenylethylidene)malononitrile and carbon disulfide or isothiocy-anatobenzene catalyzed by NaOH has been developed. This protocol has the advantages of simple operation, short reaction times, high yields, and environmental friendliness. The structures of all the products were characterized by 1H NMR, 13C NMR, IR and MS techniques. The reported method is the efficient approach for the synthesis of 2-thioxo-2H-thiopyran and 2-amino-6-thi-oxodihydropyridine derivatives.

Key words: 2-thioxo-2H-thiopyran, 2-amino-6-thioxodihydropyridine, ultrasound-assisted, synthesis