Chin. J. Org. Chem. ›› 2018, Vol. 38 ›› Issue (6): 1364-1376.DOI: 10.6023/cjoc201712031 Previous Articles     Next Articles

Special Issue: 荧光探针-生物传感合辑 有机超分子化学合辑



谢振达, 付曼琳, 尹彪, 朱勍   

  1. 浙江工业大学生物工程学院 浙江省生物有机合成重点实验室 杭州 310014
  • 收稿日期:2017-12-23 修回日期:2018-01-18 发布日期:2018-02-06
  • 通讯作者: 朱勍,
  • 基金资助:


Research Progress in 1, 8-Naphthalimide-Based Fluorescent Probes for Two-Photon Imaging

Xie Zhenda, Fu Manlin, Yin Biao, Zhu Qing   

  1. Key Laboratory of Bioorganic Synthesis of Zhejiang Province, College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310014
  • Received:2017-12-23 Revised:2018-01-18 Published:2018-02-06
  • Contact: 10.6023/cjoc201712031
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos. 21472172, 21272212).

Fluorescent imaging technology has received great attention owing to their advantageous features in high sensitivity, relatively simple operations and real-time living cells, tissue and in vivo imaging. Compared with one-photon confocal imaging, two-photon confocal imaging offers considerable advantages such as high resolution, deep-tissue depth, lower tissue auto-fluorescence and so on. As typical D-π-A two-photon dyes, 1,8-naphthalimide dyes have wide application in two-photon imaging for enzyme, reactive carbon species, reactive oxygen species, reactive nitrogen species, biothiols and ions due to their advantages such as high photostability, large Stokes/anti-Stokes shifts. According to the mechanisms of intramolecular charge transfer, photoinduced electron transfer and fluorescence resonance energy transfer, etc., the application in two-photon imaging of 1,8-naphthalimide dyes is summarized and emphasized.

Key words: 1,8-naphthalimide, fluorescent probe, D-π-A, fluorescent mechanism, two-photon imaging