Chin. J. Org. Chem. ›› 2018, Vol. 38 ›› Issue (6): 1319-1326.DOI: 10.6023/cjoc201802001 Previous Articles     Next Articles



张金刚, 吴正兴, 谢芳, 张万斌   

  1. 上海交通大学化学化工学院 上海市手性药物分子工程重点实验室 上海 200240
  • 收稿日期:2018-02-01 修回日期:2018-02-24 发布日期:2018-03-08
  • 通讯作者: 谢芳,;张万斌,;
  • 基金资助:


Metal-Catalyzed Unsaturated Hydrocarbon Functionalization Applied in the Synthesis of Pyrrolidines and Pyrrolines

Zhang Jingang, Wu Zhengxing, Xie Fang, Zhang Wanbin   

  1. Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai 200240
  • Received:2018-02-01 Revised:2018-02-24 Published:2018-03-08
  • Contact: 10.6023/cjoc201802001;
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 21572129).

Pyrrolidines and pyrrolines, as important building blocks, are widely applied in the fields of medicine, agriculture and materials. Many synthetic methods for the preparation of pyrrolidines and pyrrolines have been reported over the past few years. Recently, following the rapid development of organometallic chemistry, the metal-catalyzed functionalization of unsaturated hydrocarbons has gradually become the research focus of organic synthesis methodology, due to the high efficiency and diversity of functionalization. Therefore the constructions of pyrrolidines and pyrrolines using metal-catalyzed unsaturated hydrocarbon functionalization are important and very useful. The development of metal-catalyzed functionalizations of different types of unsaturated hydrocarbons for the synthesis of pyrrolidines and pyrrolines is summarized.

Key words: metal-catalyzed, unsaturated hydrocarbon, functionalization, pyrrolidine, pyrroline