Chin. J. Org. Chem. ›› 2018, Vol. 38 ›› Issue (7): 1772-1778.DOI: 10.6023/cjoc201802026 Previous Articles     Next Articles



石玉军a, 杜显超a, 王祥龙a, 陈庆文a, 李玲a, 戴红a, 徐蔡芹a, 张敬远a, 凌勇b   

  1. a 南通大学化学化工学院 南通 226019;
    b 南通大学药学院 南通 226001
  • 收稿日期:2018-02-26 修回日期:2018-03-09 发布日期:2018-03-16
  • 通讯作者: 戴红, 凌勇;
  • 基金资助:


Synthesis and Herbicidal Activity of Novel Cyanoacrylate Derivatives Containing Substituted Oxazole Moiety

Shi Yujuna, Du Xianchaoa, Wang Xianglonga, Chen Qingwena, Li Linga, Dai Honga, Xu Caiqina, Zhang Jingyuana, Ling Yongb   

  1. a College of Chemistry and Chemical Engineering, Nantong University, Nantong 226019;
    b School of Pharmacy, Nantong University, Nantong 226001
  • Received:2018-02-26 Revised:2018-03-09 Published:2018-03-16
  • Contact: 10.6023/cjoc201802026;
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 21372135), the Research Foundation of the Six People Peak of Jiangsu Province (No. 2013-SWYY-013), the Science and Technology Project Fund of Nantong City (No. MS22015020), and the Science and Technology Innovation Foundation for the College Students of Jiangsu Province (No. 201710304048).

In search of novel cyanoacrylates with potent bioactivity, a series of new cyanoacrylate derivatives containing substituted oxazole moiety were designed and synthesized through the strategy of active substructure combination. They were structurally characterized by 1H NMR, 13C NMR and elemental analysis. Preliminary bioassay data showed that most title compounds possessed good herbicidal activity at the dosage of 1500 g/ha, 9 compounds exhibited herbicidal activity against Brassica juncea with 80%~100%, 12 compounds had herbicidal activity against Chenopodium serotinum L. with 80%~100%, two compounds both displayed 70% herbicidal activity against Alopecurus aequalis Sobol, and one compound showed 100%, 70%, and 60% herbicidal activity against Rumex acetosa L., Polypogon fugax Nees ex Steud and Poa acroleuca Steud, respectively. Additionally, the inhibitory rates of one compound against Brassica juncea and Rumex acetosa L.were both 30% at 37.5 g/ha.

Key words: oxazole, cyanoacrylate, synthesis, herbicidal activity