Chin. J. Org. Chem. ›› 2019, Vol. 39 ›› Issue (4): 916-928.DOI: 10.6023/cjoc201807055 Previous Articles     Next Articles

Reviews

巯基类荧光探针的研究进展

闫沛沛a, 王婷b, 张丹b, 马晓雪a   

  1. a 山东医药技师学院 泰安 271000;
    b 贵州大学化学与化工学院 贵阳 550000
  • 收稿日期:2018-07-31 修回日期:2018-10-11 出版日期:2019-04-25 发布日期:2018-12-28
  • 通讯作者: 闫沛沛 E-mail:1458851831@qq.com

Progress in Fluorescence Sensors for Detection of Thiols

Yan Peipeia, Wang Tingb, Zhang Danb, Ma Xiaoxuea   

  1. a Shandong Medical Technician College, Taian 271000;
    b School of Chemistry and Chemical Engineering, Guizhou University, Guiyang 550000
  • Received:2018-07-31 Revised:2018-10-11 Online:2019-04-25 Published:2018-12-28
  • Contact: 10.6023/cjoc201807055 E-mail:1458851831@qq.com

Sulfhydryl compounds, such as cysteine (Cys), homocysteine (Hcy), glutathione (GSH) and so on, play an important role in the normal human physiological processes. Molecular fluorescent probes have attracted much attention of scholar in the detection of sulfhydryl compounds, since it has the advantage of good selectivity, high sensitivity, good biocompatibility and real-time in situ monitoring. At present, the design of thiol-based fluorescent probes is mainly based on the strong nucleophilicity of sulfhydryl groups. In this paper, the synthesis of fluorescent probes for detecting sulfhydryl compounds, which was reported from 2013 to 2018, is reviewed based on the different mechanism of the reaction between fluorescence probe and sulfhydryl, including Michael addition, cyclization of aldehyde groups, sulfonamides or sulfonates of the lysis, natural chemical linkage and so on. The detection limit of the probe, response time, equivalence ratio were elaborated.

Key words: thiols, fluorescent probe, biological thiols, research progress