Chin. J. Org. Chem. ›› 2019, Vol. 39 ›› Issue (4): 940-951.DOI: 10.6023/cjoc201810021 Previous Articles     Next Articles

Reviews

内质网靶向型有机小分子荧光探针的研究进展

张晟曦a, 牛晴旻a, 吴松泽b, 吕海娟a, 邢国文a   

  1. a 北京师范大学化学学院 北京 100875;
    b 中国人民大学附属中学 北京 100080
  • 收稿日期:2018-10-18 修回日期:2018-12-12 出版日期:2019-04-25 发布日期:2018-12-28
  • 通讯作者: 邢国文 E-mail:gwxing@bnu.edu.cn
  • 基金资助:

    国家自然科学基金(No.21272027)资助项目.

Recent Progress on Endoplasmic Reticulum-Targetable Small Organic Fluorescent Probes

Zhang Shengxiaa, Niu Qingminaa, Wu Songzebb, Lü Haijuanaa, Xing Guowena   

  1. a College of Chemistry, Beijing Normal University, Beijing 100875;
    b The High School Affiliated to Renmin University of China, Beijing 100080
  • Received:2018-10-18 Revised:2018-12-12 Online:2019-04-25 Published:2018-12-28
  • Contact: 10.6023/cjoc201810021 E-mail:gwxing@bnu.edu.cn
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No.21272027).

Endoplasmic reticulum (ER) is an important organelle in eukaryotic cells and participates in the synthesis and secretion of various proteins, glycogen, lipids, and cholesterol substances. It is surrounded by a single membrane in the cytoplasm, which is a three-dimensional mesh structure formed by flat cysts, membrane tubes, and bubbles. Research on the physiological morphology of ER can facilitate the resolution of certain metabolic diseases. Due to the good optical properties and outstanding specific localization, fluorescent probe technology has been widely used in structural investigation and activity tracking of organelles. The ER fluorescent probes can be divided into two types, one is a single functional ER localization probe, the other is a multi-functional ER probe, which has multiple functions of locating and detecting active species in ER, the morphology and environment of ER. In this article, the structure, function and biological application of ER fluorescent probes in recent years are summarized and reviewed. Various localization mechanisms of ER fluorescent probes are described. The development trend of ER fluorescent probes in life science research is prospected.

Key words: endoplasmic reticulum, fluorescent probe, targetable localization, multi-functional probe