Chin. J. Org. Chem. ›› 2019, Vol. 39 ›› Issue (9): 2345-2364.DOI: 10.6023/cjoc201903006 Previous Articles     Next Articles

Special Issue: 碳氢活化合辑2018-2019



祝志强, 肖利金, 谢宗波, 乐长高   

  1. 东华理工大学化学生物与材料科学学院 核资源与环境国家重点实验室 南昌 330013
  • 收稿日期:2019-03-03 修回日期:2019-04-15 发布日期:2019-04-26
  • 通讯作者: 祝志强, 谢宗波, 乐长高;;
  • 基金资助:


Recent Advances in the α-C(sp3)-H Bond Functionalization of Glycine Derivatives

Zhu Zhiqiang, Xiao Lijin, Xie Zongbo, Le Zhanggao   

  1. State Key Laboratory of Nuclear Resources and Environment, School of Chemistry, Biology and Material Science, East China University of Technology, Nanchang 330013
  • Received:2019-03-03 Revised:2019-04-15 Published:2019-04-26
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos. 21602027, 11765002), the Foundation of Jiangxi Educational Committee (No. GJJ170458) and the China Postdoctoral Science Foundation (No. 2018M632595).

α-Amino acids are the units of proteins, which not only widely occur in many biological important compounds and natural products, but also are useful as organic catalysts or ligands for asymmetric synthesis. Among them, glycines are particularly useful building blocks in organic synthesis. Direct C(sp3)-H bond functionalization of glycine derivatives provided an attractive synthesis strategy for the construction of a variety of α-substituted α-amino acids. The recent progress in the α-C(sp3)-H bond activation of glycine derivatives, with various reagents to form carbon-carbon and carbon-heteroatom bond, and oxidative coupling/cyclization reaction involving glycine derivatives is reviewed.

Key words: glycines, C-H bond, functionalization, cross-dehydrogenative-coupling, cascade cyclization