Chin. J. Org. Chem. ›› 2019, Vol. 39 ›› Issue (9): 2392-2402.DOI: 10.6023/cjoc201903025 Previous Articles     Next Articles



张晓鹏, 朱妍洁, 朱奕崧, 李政伟, 张贵生   

  1. 河南师范大学化学化工学院 绿色化学介质与反应教育部重点实验室 河南省有机功能分子与药物创新重点实验室 精细化学品绿色制造河南省协同创新中心 新乡 453007
  • 收稿日期:2019-03-14 修回日期:2019-04-11 发布日期:2019-04-26
  • 通讯作者: 张晓鹏
  • 基金资助:


Advances in Synthesis of 2,3-Dihydroquinazolin-4(1H)-ones

Zhang Xiaopeng, Zhu Yanjie, Zhu Yisong, Li Zhengwei, Zhang Guisheng   

  1. Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals, Henan Key Laboratory of Organic Functional Molecule and Drug Innovation, Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang 453007
  • Received:2019-03-14 Revised:2019-04-11 Published:2019-04-26
  • Contact: 10.6023/cjoc201903025
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos. 21772033, U1604285) and the Program of Introducing Talents of Discipline to Universities (111 Project, No. D17007).

2,3-Dihydroquinazolin-4(1H)-one compounds are an important class of nitrogen-containing fused heterocycles, which possess a wide range of pharmacological and biological activities and have important applications in the fields of synthesis and research & development of drugs. Therefore, its synthetic methods have also attracted considerable attention. In this paper, the main advances in the synthesis of 2,3-dihydroquinazolin-4(1H)-ones and their proposed reaction mechanisms from the raw materials such as o-aminobenzamides, isatoic anhydrides, o-nitrobenzamides, o-azidobenzamide, o-bromo-benzamide, o-bromobenzonitrile, o-aminobenzoic acids, o-aminobenzonitrile, o-amino-N-(propa-1,2-dienyl)benzamides, and N-alkyl anilines were introduced and reviewed, respectively. Finally, the synthesis of these compounds was summarized and the prospect of their development was prospected.

Key words: 2,3-dihydroquinazolin-4(1H)-one, o-aminobenzamides, isatoic anhydrides, N-alkyl anilines, C-H activation &, functionalization, palladium catalysis