Chinese Journal of Organic Chemistry ›› 2020, Vol. 40 ›› Issue (5): 1367-1371.DOI: 10.6023/cjoc201912012 Previous Articles     Next Articles


张捷a,b, 陈玉婵a, 刘昭明a, 郭波红b, 高晓霞b, 刘洪新a, 章卫民a   

  1. a 广东省微生物研究所 广东省科学院 华南应用微生物国家重点实验室 广东省菌种保藏与应用重点实验室 广东省微生物应用新技术公共实验室;
    b 广东药科大学药学院 广州 510006
  • 收稿日期:2019-12-09 修回日期:2020-01-05 发布日期:2020-01-15
  • 通讯作者: 刘洪新, 章卫民;
  • 基金资助:

Cytotoxic Secondary Metabolites from a Sea-Derived Fungal Strain of Hypoxylon rubiginosum FS521

Zhang Jiea,b, Chen Yuchana, Liu Zhaominga, Guo Bohongb, Gao Xiaoxiab, Liu Hongxina, Zhang Weimina   

  1. a State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Open Laboratory of Applied Microbiology, Guangdong Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou 510070;
    b School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006
  • Received:2019-12-09 Revised:2020-01-05 Published:2020-01-15
  • Supported by:
    Project supported by the National Natural Science Foundation of China (Nos. 41906106, 31272087), the Pearl River Science and Technology New Star Fund of Guangzhou Province (No. 201806010080), the Team Project of the Natural Science Foundation of Guangdong Province (No. 2016A030312014), and the Project of Science and Technology Development of Guangdong Academy of Sciences (No. 2019GDASYL-0103007).

One new compound, named hypoxone A (1), together with two new natural products 4,8-dimethoxy-1-naphthol (2) and 1'-hydroxy-4',8,8'-trimethoxy[2,2']binaphthalenyl-1,4-dione (3), and fourteen known derivatives 4~17 were isolated from the broth extract of the marine fungus Hypoxylon rubiginosum FS521, which was isolated from a deep-sea sediment sample. Their structures were elucidated by interpretation of spectroscopic analysis and comparison with previously published data for the known ones. Moreover, compounds 1~4 were evaluated for their in vitro cytotoxic activities against SF-268, MCF-7, HepG-2, and A549 tumor cell lines, and compound 3 exhibited potent cytotoxic activity with IC50 values of 1.85, 3.21, 2.53, and 5.09 mmol·L-1, respectively.

Key words: marine fungus, Hypoxylon rubiginosum, cytotoxicity, polyketides