Chinese Journal of Organic Chemistry ›› 2020, Vol. 40 ›› Issue (5): 1087-1095.DOI: 10.6023/cjoc202002017 Previous Articles     Next Articles

ACCOUNT

基于配位辅助的烯烃催化不对称炔氢化

张雯雯, 王紫璇, 白小燕, 李必杰   

  1. 清华大学化学系基础分子科学中心 北京 100084
  • 收稿日期:2020-02-16 修回日期:2020-03-08 出版日期:2020-05-25 发布日期:2020-03-31
  • 通讯作者: 李必杰 E-mail:bijieli@mail.tsinghua.edu.cn
  • 基金资助:
    青年千人计划资助项目.

Substrate-Directed Catalytic Asymmetric Hydroalkynylation of Alkenes

Zhang Wenwen, Wang Zixuan, Bai Xiaoyan, Li Bijie   

  1. Center of Basic Molecular Science (CBMS), Department of Chemistry, Tsinghua University, Beijing 100084
  • Received:2020-02-16 Revised:2020-03-08 Online:2020-05-25 Published:2020-03-31
  • Supported by:
    Project supported by the Thousand Young Talents Program.

Catalytic asymmetric hydrofunctionalization of alkene is an important research field, which enables efficient construction of chiral molecules from readily available starting materials. Asymmetric hydrofunctionalization of multiple substituted alkenes represents a significant challenge to organic chemists because this process involves the simutaneous control of regio-, diastereo-, and enantio-selectivities. The key to solve this challenge is to identify novel catalyst systems to exert powerful regio- and stereo-control. Recently, by taking advantage of substrate-directed strategy, we have developed a number of alkene functionalization methods with excellent regio-, diastereo-, and enantio-selectivities. In particular, we focus on catalytic asymmetric hydroalkynylation of alkenes as a model transformation to analyze the factors that control the selectivity.

Key words: alkene functionalization, asymmetric catalysis, selectivity, substrate-directed strategy, transition metal catalysis