Substrate-Directed Catalytic Asymmetric Hydroalkynylation of Alkenes

doi:10.6023/cjoc202002017

Abstract

Catalytic asymmetric hydrofunctionalization of alkene is an important research field, which enables efficient construction of chiral molecules from readily available starting materials. Asymmetric hydrofunctionalization of multiple substituted alkenes represents a significant challenge to organic chemists because this process involves the simutaneous control of regio-, diastereo-, and enantio-selectivities. The key to solve this challenge is to identify novel catalyst systems to exert powerful regio- and stereo-control. Recently, by taking advantage of substrate-directed strategy, we have developed a number of alkene functionalization methods with excellent regio-, diastereo-, and enantio-selectivities. In particular, we focus on catalytic asymmetric hydroalkynylation of alkenes as a model transformation to analyze the factors that control the selectivity.

Key words: alkene functionalization, asymmetric catalysis, selectivity, substrate-directed strategy, transition metal catalysis

Cite this article

Zhang Wenwen, Wang Zixuan, Bai Xiaoyan, Li Bijie. Substrate-Directed Catalytic Asymmetric Hydroalkynylation of Alkenes[J]. Chinese Journal of Organic Chemistry, 2020, 40(5): 1087-1095.

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