Chinese Journal of Organic Chemistry ›› 2021, Vol. 41 ›› Issue (1): 241-249.DOI: 10.6023/cjoc202006023 Previous Articles     Next Articles



李娇娇a, 班立夫a, 汤立军a,*()   

  1. a 渤海大学化学化工学院 辽宁锦州 121013
  • 收稿日期:2020-06-12 修回日期:2020-07-08 发布日期:2020-08-01
  • 通讯作者: 汤立军
  • 作者简介:
    * Corresponding author. E-mail:
  • 基金资助:
    国家自然科学基金(21878023); 国家自然科学基金(U1608222); 辽宁省特聘教授支持计划资助项目.

Research Progress in Mitochondrial Targeting Fluorescent Probes for Hydrogen Peroxide

Jiaojiao Lia, Lifu Bana, Lijun Tanga,*()   

  1. a College of Chemistry and Chemical Engineering, Bohai University, Jinzhou, Liaoning 121013
  • Received:2020-06-12 Revised:2020-07-08 Published:2020-08-01
  • Contact: Lijun Tang
  • Supported by:
    the National Natural Science Foundation of China(21878023); the National Natural Science Foundation of China(U1608222); the Program for Distinguished Professor of Liaoning Province

Controlling the content of mitochondrial hydrogen peroxide can play a beneficial role in cell survival, growth, differentiation and maintenance. However, the abnormal production of mitochondrial hydrogen peroxide may destroy the structure of biological macromolecules and cells, and promote the occurrence of aging, mutation and even cancer. Therefore, there is an urgent need for means to effectively monitor changes in hydrogen peroxide levels in living cells, especially in mitochondria. To this end, a variety of fluorescent probes have been developed and designed to monitor changes in hydrogen peroxide levels in mitochondria. The recent progress in mitochondrial targeting fluorescent probes for hydrogen peroxide based on the structure of targeting groups is summarized, and triphenylphosphonium probes, pyridinium probes, quinolinium probes, indolium probes, and other cationic probes are introduced, including the structure, fluorescence behavior and biological imaging of these probes. These fluorescent probes will become powerful molecular tools in future disease diagnosis and pathological research.

Key words: hydrogen peroxide, mitochondria, fluorescent probe, positively charged group, sensing mechanism