Chinese Journal of Organic Chemistry ›› 2020, Vol. 40 ›› Issue (12): 4350-4356.DOI: 10.6023/cjoc202007029 Previous Articles     Next Articles


戴红a, 梁凯a, 周钱a, 倪亚丹a, 钱程a, 钱宏炜a, 李玲a, 石玉军a, 梁志鹏b, 石健b, 高磊a, 吴新星a   

  1. a 南通大学化学化工学院 江苏南通 226019;
    b 南通大学分析测试中心 江苏南通 226019
  • 收稿日期:2020-07-09 修回日期:2020-07-28 发布日期:2020-08-01
  • 通讯作者: 吴新星
  • 基金资助:

Synthesis and Biological Activities of Novel Pyrazole Amide Compounds Containing Substituted Oxazole Unit

Dai Honga, Liang Kaia, Zhou Qiana, Ni Yadana, Qian Chenga, Qian Hongweia, Li Linga, Shi Yujuna, Liang Zhipengb, Shi Jianb, Gao Leia, Wu Xinxinga   

  1. a College of Chemistry and Chemical Engineering, Nantong University, Nantong, Jiangsu 226019;
    b Analysis and Testing Center, Nantong University, Nantong, Jiangsu 226019
  • Received:2020-07-09 Revised:2020-07-28 Published:2020-08-01
  • Supported by:
    Project supported by the National Natural Science Foundation of China (No. 21372135), the Science and Technology Project Fund of Nantong City (No. MS12019060) and the Program of High-Level Talents of Nantong University (No. 03083031).

In search of new pyrazole amide derivatives with wonderful bioactivities, fifteen novel pyrazole amide compounds were designed and synthesized by introducing substituted oxazole unit into pyrazole amide skeleton based on the lead compound tebufenpyrad. The structures of the title compounds were confirmed by 1H NMR, 13C NMR and elemental analysis. The preliminary bioassay data exhibited that most of target compounds had more than 90% insecticidal activities against Oriental armyworm at the concentration of 500 μg/mL. At the concentration of 500 μg/mL, one compound displayed 100% mortality rate against Aphis medicaginis. In addition, two compounds showed 30% insecticidal activity against Tetranychus cinnabarinus at the concentration of 500 μg/mL.

Key words: oxazole, pyrazole amide, synthesis, biological activity