Chinese Journal of Organic Chemistry ›› 2022, Vol. 42 ›› Issue (5): 1307-1325.DOI: 10.6023/cjoc202110036 Previous Articles     Next Articles



雍灿, 李芸, 毕涛, 陈国凤, 郑东霞, 王周玉*(), 张园园*()   

  1. 西华大学理学院化学系 成都 610039
  • 收稿日期:2021-10-25 修回日期:2022-01-10 发布日期:2022-01-27
  • 通讯作者: 王周玉, 张园园
  • 基金资助:

Research Progress on the Synthesis and Activity of D-Galactose Derived Small Galectin Inhibitors

Can Yong, Yun Li, Tao Bi, Guofeng Chen, Dongxia Zheng, Zhouyu Wang(), Yuanyuan Zhang()   

  1. Department of Chemistry, School of Science, Xihua University, Chengdu 610039
  • Received:2021-10-25 Revised:2022-01-10 Published:2022-01-27
  • Contact: Zhouyu Wang, Yuanyuan Zhang
  • Supported by:
    Chunhui Project of Ministry of Education(Z2016164)

Galectins are a family of soluble proteins which can specifically recognize the structure of β-galactoside. It is widely distributed in normal and diseased tissues, and plays an important role in cell adhesion, cell apoptosis, inflammatory response, tumor metastasis and other related processes. Galectin is a promising target for the treatment of many diseases, such as tumor, inflammation and neurological diseases. Herein, the synthesis and biological activities of small galectin inhibitors derived from D-galactose are reviewed according to the difference of derivatization sites, which are expected to provide research thought for designing galectin inhibitors with high affinity and high selectivity, and afford reference for development of new drug candidates targeting galectins.

Key words: galectin, inhibitor, synthesis, biological activity, research progress