Chinese Journal of Organic Chemistry ›› 2023, Vol. 43 ›› Issue (6): 2081-2095.DOI: 10.6023/cjoc202210034 Previous Articles     Next Articles


刘甜甜, 张鸿鹏, 焦晓梦, 白银娟*()   

  1. 西北大学化学与材料科学学院 合成与天然功能分子教育部重点实验室 西安 710127
  • 收稿日期:2022-10-27 修回日期:2022-12-02 发布日期:2022-12-28
  • 基金资助:

Research Progress of Multi-signal Fluorescent Probes for Simultaneous Detection of Biothiols

Tiantian Liu, Hongpeng Zhang, Xiaomeng Jiao, Yinjuan Bai*()   

  1. Key Laboratory of Synthetic and National Functional Molecule Chemistry of the Ministry of Education, College of Chemistry & Material Science, Northwest University, Xi'an 710127
  • Received:2022-10-27 Revised:2022-12-02 Published:2022-12-28
  • Contact: E-mail:
  • Supported by:
    National Natural Science Foundation of China(21042002)

There is a close relationship between different biothiols. The changes of one biothiol level in a specific cell metabolism process may be related to the variation of another biothiol, and many diseases are the result of the combination of two or more biothiols. The simultaneous detection of divers biological thiols by fluorescence method is of particular importance for biological research and disease diagnosis. In recent years, breakthrough results have been achieved in this field. The research progress of multi-signal fluorescent probes in the field of simultaneous detection of biothiols is reviewed. According to the objects detected by the probes, the fluorescent probes are systemically classified and discussed, and the corresponding design concept, optical properties, detection mechanism, recognition performance and biological applications are summarized. At the same time, the future development and application in this field are proposed.

Key words: biothiol, fluorescent probe, simultaneous detection, multi-signal