Eight novel chalcone compounds 1a～1h were synthesized by esterification, methoxymethyl protection or methylation, hydrazidation, oxidation, aldol condensation, deprotection, O-farnesylation or O-prenylation respectively using 3,5-dihydroxybenzoic acid as starting material in overall yield of 5.6%～46%. Their structures were confirmed by ¹H NMR, ¹³C NMR, IR and MS spectra. Target compounds were screened with three international stan-dard models for biological activity. Results showed that 1b against model CAT-B and 1e against model CDC25 possessed the good inhibition activity.

Key words: prenyloxy chalcone, synthesis, farnesyloxy chalcone, biological activity, hydroxylated chalcone