Chin. J. Org. Chem. ›› 2006, Vol. 26 ›› Issue (10): 1437-1443. Previous Articles     Next Articles




  1. (西北大学生命科学院 西部资源生物与现代生物技术省部共建教育部重点实验室 西安 710069)
  • 收稿日期:2005-11-01 修回日期:2006-03-20 发布日期:2006-09-19
  • 通讯作者: 刘建利

Progress in the Synthesis of Rutaecarpine

WANG Cui-Ling,LIU Jian-Li*,LING Ya-Ping   

  1. (Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, School of Life Science, Northwest University, Xi′an 710069)
  • Received:2005-11-01 Revised:2006-03-20 Published:2006-09-19
  • Contact: LIU Jian-Li

Rutaecarpine belongs to the quinazolinocarboline type of alkaloids isolated from the fruits of Evodia rutaecarpa, which has been used in traditional Chinese medicine under the name Wu-Zhu-Yu against e.g. headache, dysentery, cholera, worm infections and postpartum disturbances. In literature, rutae-carpine and its derivatives have been reported to have cycloxygenase (COX-2) inhibitory, hypotensive, an-tiarrhythmic, antiplatelet aggregation, vasorelaxation and anti-anoxic activities. Owing to its pharmaceutical activities, attention is still focused on the development of new synthetic methods for rutaecarpine. Several methods of synthesis of rutaecarpine are reviewed according to the types of building chemical structures. Rutaecarpine was mostly made by tryptamine and anthranilic acid or their derivaties through complicated steps. So, the simple and convenient methods are still needed.

Key words: tryptamine, biosynthesis, anthranilic acid, synthesis, rutaecarpine