Chin. J. Org. Chem. ›› 2009, Vol. 29 ›› Issue (10): 1659-1663. Previous Articles     Next Articles

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3-(2-取代噻唑-4-基)愈创兰烃薁的合成及抗菌活性

王道林* 韩 珊 黄孝东 谷 峥   

  1. (渤海大学化学化工学院 辽宁省应用化学重点实验室 锦州 121003)
  • 收稿日期:2008-12-24 修回日期:2009-03-10 发布日期:2009-05-27

Synthesis of 3-(2-Substituted thiazol-4-yl)guaiazulenes and Their Antibacterial Activity

Wang, Daolin* Han, Shan Huang, Xiaodong Gu, Zheng   

  1. (Liaoning Key Laboratory of Applied Chemistry, College of Chemistry and Chemical Engineering, Bohai University, Jinzhou 121003)
  • Received:2008-12-24 Revised:2009-03-10 Published:2009-05-27

3-(2-Substituted thiazol-4-yl)guaiazulene derivatives were synthesized by the condensation of 3-(chloroacetyl)guaiazulene with thiourea, substituted thioureas or thioacetamide under mild conditions with good yields. All the compounds were fully characterized by 1H NMR, IR spectra and elemental analysis, and the bioassay result indicated that some of the title compounds had markedly antibacterial activity.

Key words: azulene, 3-chloroacylguaiazulene, synthesis