Synthesis and Bioactivities of Novel Pyrazole Amides Carrying Oxazole Moiety

doi:10.6023/cjoc202001028

Chinese Journal of Organic Chemistry ›› 2020, Vol. 40 ›› Issue (6): 1772-1778.DOI: 10.6023/cjoc202001028 Previous Articles Next Articles

新型含噁唑单元的吡唑酰胺衍生物的合成及其生物活性

张敏^a, 郑丹丹^a, 倪亚丹^a, 梁凯^a, 荀校^a, 胡兰萍^a, 陈庆文^a, 杨冰^a, 梁志鹏^b, 丁颖^a, 石健^b, 戴红^a

a 南通大学化学化工学院江苏南通 226019;
b 南通大学分析测试中心江苏南通 226019

收稿日期:2020-01-20 修回日期:2020-02-27 发布日期:2020-03-06
通讯作者: 胡兰萍, 杨冰, 戴红 E-mail:hlp@ntu.edu.cn;yangbing111@ntu.edu.cn;daihong_2015@aliyun.com
基金资助:
国家自然科学基金（No.21372135）、南通市科技计划（No.MS12019060）资助项目.

Synthesis and Bioactivities of Novel Pyrazole Amides Carrying Oxazole Moiety

Zhang Min^a, Zheng Dandan^a, Ni Yadan^a, Liang Kai^a, Xun Xiao^a, Hu Lanping^a, Chen Qingwen^a, Yang Bing^a, Liang Zhipeng^b, Ding Ying^a, Shi Jian^b, Dai Hong^a

a College of Chemistry and Chemical Engineering, Nantong University, Nantong, Jiangshu 226019;
b Analysis and Testing Center, Nantong University, Nantong, Jiangshu 226019

Received:2020-01-20 Revised:2020-02-27 Published:2020-03-06
Supported by:
Project supported by the National Natural Science Foundation of China (No. 21372135) and the Science and Technology Project Fund of Nantong City (No. MS12019060).

1. 201772S.pdf(991KB)

Abstract

In order to find new pyrazole amides with wonderful bioactivities, a series of novel pyrazole amide derivatives were synthesized by introducing substituted oxazole ring into the C-5 position of pyrazole skeleton based on the lead chlorantraniliprole. The aimed compounds were structurally characterized through ¹H NMR, ¹³C NMR and elemental analysis. The preliminary bioassay results exhibited that all the title compounds displayed more than 90% insecticidal activities against Mythimna separata (Walker) at 500 μg/mL. At the dosage of 100 μg/mL, five compounds possessed 90%~100% insecticidal activities against Mythimna separata (Walker), and three compounds exhibited insecticidal property against Aphis craccivora with 90%~100%. Additionally, at the dosage of 500 μg/mL, two compounds possessed insecticidal activity against Tetranychus cinnabarinus with 80%~100%.

Key words: oxazole, pyrazole amide, synthesis, bioactivity

Cite this article

Zhang Min, Zheng Dandan, Ni Yadan, Liang Kai, Xun Xiao, Hu Lanping, Chen Qingwen, Yang Bing, Liang Zhipeng, Ding Ying, Shi Jian, Dai Hong. Synthesis and Bioactivities of Novel Pyrazole Amides Carrying Oxazole Moiety[J]. Chinese Journal of Organic Chemistry, 2020, 40(6): 1772-1778.

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新型含噁唑单元的吡唑酰胺衍生物的合成及其生物活性

Synthesis and Bioactivities of Novel Pyrazole Amides Carrying Oxazole Moiety

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