Chinese Journal of Organic Chemistry ›› 2021, Vol. 41 ›› Issue (2): 826-832.DOI: 10.6023/cjoc202006037 Previous Articles     Next Articles



余玮a, 王翰a, 闵莉静b, 华学文c, 刘幸海a,*()   

  1. a 浙江工业大学化学工程学院 杭州 310014
    b 湖州师范学院生命科学院 浙江湖州 313000
    c 聊城大学农学院 山东聊城 252000
  • 收稿日期:2020-06-19 修回日期:2020-07-20 发布日期:2020-10-22
  • 通讯作者: 刘幸海
  • 作者简介:
    * Corresponding author. E-mail:
  • 基金资助:
    浙江省自然科学基金(LY19C140002); 浙江省教育厅(Y201941832)

Synthesis and Fungicidal Activity of Novel Allyl Benzoate Compounds Containing Triazole

Wei Yua, Han Wanga, Li-Jing Minb, Xue-Wen Huac, Xing-Hai Liua,*()   

  1. a College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014
    b Key Laboratory of Vector Biology and Pathogen Control of Zhejiang Province, College of Life Science, Huzhou University, Huzhou, Zhejiang 313000
    c College of Agriculture, Liaocheng University, Liaocheng, Shandong 252000
  • Received:2020-06-19 Revised:2020-07-20 Published:2020-10-22
  • Contact: Xing-Hai Liu
  • Supported by:
    the Natural Science Foundation of Zhejiang Province(LY19C140002); the Research Fund of Department of Education of Zhejiang Province(Y201941832)

In order to find pesticide lead compounds with high fungicidal activity, a series of unreported allyl benzoate compounds containing triazole were designed and synthesized. The structures were confirmed by 1H NMR and HRMS, and the crystal structure of (R,S)-(Z)-1,3-diphenyl-2-(1H-1,2,4-triazol-1-yl)allyl 2,3-dichlorobenzoate (5j) was determined by X-ray single crystal diffraction. The bioassay results showed that (R,S)-(Z)-1,3-diphenyl-2-(1H-1,2,4-triazol-1-yl)allyl benzoate (5a), (R,S)-(Z)-1,3-diphenyl-2-(1H-1,2,4-triazol-1-yl)allyl 2-fluorobenzoate (5g) and (R,S)-(Z)-1,3-diphenyl-2-(1H-1,2,4-triazol-1- yl)allyl 3-methylbenzoate (5n) exhibited good control efficacy against Sclerotinia sclerotiorummore than 70% at 50 mg/L.

Key words: triazole fungicide, synthesis, fungicidal activity, structure activity relationship (SAR)