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化学学报
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化学学报 ›› 1997, Vol. 55 ›› Issue (6): 617-621. 上一篇    下一篇

研究论文

纤维素三(3, 5-二硝基)苯甲酸酯手性固定相的制备和应用研究

邹公伟;郑琦;胡冠九;邵宇;施耀曾   

  1. 南京大学化学系.南京(210008)
  • 发布日期:1997-06-15

Study on the preparation and application of cellulose tris(3, 5- dinitro) benzoate as chiral stationary phase

Zou Gongwei;Zheng Qi;Hu Guanjiu;Shao Yu;Shi Yaozeng   

  1. Nanjing Univ, Dept Chem.Nanjing(210008)
  • Published:1997-06-15

PDF

388

被引次数

20

纤维素三(3,5-二硝基)苯甲酸酯用超声反应合成,具有反PirkleI型手性固定相的结构,将其涂布在大孔硅胶载体上,用作一种新的高效液相色谱手性固定相,成功地拆分了布洛芬和氰戊菊酯的中间体。讨论了其分离的机理。

关键词: 应用, 制备, 手性固定相, 苯甲酸酯, 纤维素, 三苯甲酯, 氰戊菊酯, 布洛芬, 消旋体拆分, 超声反应

Cellulose tris(3, 5-dinitro) benzoate (CTNB) was ultra-sonically synthesized as a reversed Pirkle chiral stationary phase (CSP) type I. After coating on macroporous silica gel, the chiral separation ability was studied as HPLC CSP. The resolution of ibuprofenum was performed with γ=1.25, the resolution of an esfenvalerate intermediate was also achieved (γ=1.39). The mechanism and model of separation were discussed.

Key words: APPLICATION, PREPARATION, BENZOIC ETHER, CELLULOSE, FENVALERATE, IBUPROFEN, MESOTOMY

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