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化学学报
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化学学报 ›› 2003, Vol. 61 ›› Issue (2): 279-284. 上一篇    下一篇

研究论文

氢化铝锂还原α，β-不饱和羰基化合物的新反应——一种合成l，3-二醇的简便方法

李洋;王峰;曹小平   

  1. 兰州大学化学化工学院
  • 发布日期:2003-02-15

A Novel Practical Reaction of a, /f-Unsaturated Esters and Ketones with Lithium Aluminum Hydride ------A Facile Route to 1,3-Diols

Li Yang;Wang Feng;Cao Xiaoping   

  1. State Key Laboratory of Applied Organic Chemistry,College of Chemistry and Chemical Engineering,Lanzhou University
  • Published:2003-02-15

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1

在0℃下，以四氢呋喃为溶剂，用氢化铝锂还原α，β-不饱和酯和配，除得到 正常的还原产物一醇外，还以适中的产率方便地得到1，3—二醇，该反应原料易得 ，操作简单，有望应用于合成含有1，3—二醇骨架结构的天然产物。

关键词: 羰基化合物, 氧化铝锂, 还原, 四氢呋喃

A novel reaction of a, β-unsaturated esters and ketones with lithium aluminum hydride in dry tetrahydrofuran solution at 0℃ affords, in addition to saturated and unsaturated alcohols, the corresponding 1,3-diols in moderate yield. The utility of the transformation is available for staring materials. The synthetic routes are facile and the reactions can be performed on molar scales. Direct application can be expected in the synthesis of the natural products containing 1,3-diol structural unit.

Key words: CARBONYL COMPOUNDS, ALUMINIUM LITHIUM HYD, REDUCTION, TETRAHYDROFURAN

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