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化学学报
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化学学报 ›› 1993, Vol. 51 ›› Issue (11): 1133-1138. 上一篇    下一篇

研究论文

四川轮环藤根中两种海岛轮环藤-N-氧化物的分离鉴定

赖盛;赵同芳;王宪楷;志津里芳一;山村庄亮   

  1. 华西医科大学药学院;日本庆应大学理工学部
  • 发布日期:1993-11-15

Two novel insularine-N-oxides from the roots of cyclea sutchuenensis gagnep

LAI SHENG;ZHAO TONGFANG;WANG XIANKAI;ZHI JINLIFANGYI;SHAN CUNZHUANGLIANG   

  • Published:1993-11-15

PDF

420

被引次数

5

从中国特有植物四川轮环藤(Cyclea sutchuenensis Gagnep.)根中分得两种海岛轮环藤碱-N-氧化物。采用波谱分析和化学方法鉴定, 证明分别为海岛轮环藤碱-2β-N-氧化物(3)和海岛轮环藤碱-2'β-N-氧化物(4)。二者均为新生物碱, 是首尾氧桥双苄基异喹啉生物碱-N-氧化物。从该植物根中还分得已知的海岛轮环藤碱(1)和海岛轮环藤酚碱(2)。本文首次详细报道并分析了2的1^H NMR和13^C NMR数据。经三种人癌细胞实验, 证明2具有显著的抗癌活性。

关键词: 分离, 碳13核磁共振谱法, 双苄基异喹啉生物碱, 质子磁共振谱法, 抗癌活性, 轮环藤, 海岛轮环藤碱, 海岛轮环藤酚碱

Two novel insularine-N-oxides, insularine-2b-N-oxide (I) and insularine-2'b-N-oxide (II), were isolated along with insularine and insulanoline from the roots of C. sutchuenensis indigenous only to China. Their structures have been elucidated on the basis of spectral anal. and confirmed by chem. correlation with insularine. Both I and II are rare examples of naturally occurring head-to-tail bisbenzylisoquinoline N-oxides. Additional, the 1H and 13C NMR spectral data of insulanoline were first reported and assigned in detail. Insulanoline showed significant inhibitory activity against human colon adenocarcinoma.

Key words: SEPARATION, C13 NMR SPECTROMETRY, BISBENZYL ISOQUINOLINE ALKALOID, PROTON MAGNETIC RESONANCE SPECTROMETRY, ANTINEOPLASTIC ACTIVITY

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