有机化学 ›› 2012, Vol. ›› Issue (03): 624-626.DOI: 10.6023/cjoc1105181 上一篇    下一篇

研究简报

MoO3/Al2O3 催化氧化选择性合成亚砜

孙莉, 杨振平, 郭罕奇, 裴文   

  1. 浙江工业大学化学工程与材料学院 杭州 310014
  • 收稿日期:2011-05-18 修回日期:2011-10-19 发布日期:2012-03-24
  • 通讯作者: 裴文 E-mail:peiwen58@zjut.edu.cn

Selective Synthesis of Sulfoxides by Oxidation Using MoO3/Al2O3 as Catalyst

Sun Li, Yang Zhenping, Guo Hanqi, Pei Wen   

  1. College of Chemical Engineering and Materials, Zhejiang University of Technology, Hangzhou 310014
  • Received:2011-05-18 Revised:2011-10-19 Published:2012-03-24

采用浸渍法制备了不同负载量的MoO3/Al2O3 催化剂, 讨论了MoO3, Al2O3 和MoO3/Al2O3 负载的催化剂作用下,利用H2O2 进行硫醚氧化制亚砜的反应. 结果显示MoO3/Al2O3 催化剂负载量为20%时催化活性最高, 原料转化率达100%, 且没有副产物生成. 将该方法应用到兰索拉唑前体的氧化反应中, 收率达到80%. 催化剂重复使用6 次不失活.

关键词: MoO3/Al2O3, 亚砜, 兰索拉唑, 氧化反应

MoO3/Al2O3 solid base catalysts were prepared by impregnation method and the catalytic activity of MoO3, Al2O3 and MoO3/Al2O3 were investigated in the oxidation reaction of sulfoether to sulfoxide using H2O2 as oxidant. The result indicated that the conversion was 100% and no by-product produced when the catalyst of MoO3/Al2O3 loaded 20% of MoO3. Then, the intermediate of lansoprazole was oxidated by using the same method to get the corresponding lansoprazole in the yield of 80%. The catalyst could be used 6 times without deactivity.

Key words: MoO3/Al2O3, sulfides, lansoprazole, oxidationg reaction