有机化学 ›› 2012, Vol. 32 ›› Issue (07): 1208-1216.DOI: 10.6023/cjoc1108122 上一篇    下一篇

综述与进展

直接活化芳香C—H 键构建芳香C—N 键的研究进展

徐娟, 魏真, 李加荣   

  1. 北京理工大学化工与环境学院 北京 100081
  • 收稿日期:2011-08-12 修回日期:2012-01-11 发布日期:2012-02-08
  • 通讯作者: 李加荣 E-mail:jrli@bit.edu.cn

Research Progress in the Construction of Aromatic C—N Bond from Activation of Aromatic C—H Bond

Xu Juan, Wei Zhen, Li Jiarong   

  1. School of Chemical Engineering and Environment, Beijing Institute of Technology, Beijing 100081
  • Received:2011-08-12 Revised:2012-01-11 Published:2012-02-08

芳香C—N 键广泛存在于药物、活性天然产物和农药中, 其构建方法是目前合成热点之一. 芳香C—H 键到芳香C—N 键的转化是重要的有机转化类型, 这种转化是构成芳胺的一种高效方法. 这种直接转化具有原子经济性, 可持续发展性以及环境友好的特点. 主要以芳香C—H 键的氮宾插入和氧化胺化为主线, 综述了近十年来该领域的研究进展.

关键词: 芳香C—H 键的活化, 胺化, 芳胺, 氮宾插入, 氧化胺化

Amines are important compounds that are found throughout the pharmaceutical, bioactive natural products and agrochemical industries. The transformation from aromatic C—H bond to aromatic C—N bond is an important organic conversion. It is an effective method for the construction of aromatic amine. This transformation has the characteristic of atom economy, sustainable development and environment friendly. This review is focused on the research progress in the direct amination of C—H bonds in the past decade.

Key words: activation of aromatic C—H bond, amination, aromatic amine, nitrene insertion, oxidative amination