有机化学 ›› 2012, Vol. 32 ›› Issue (07): 1340-1343.DOI: 10.6023/cjoc1109033 上一篇    下一篇

研究简报

利用Diels-Alder 反应构建桉烷类倍半萜骨架关键中间体的研究

张宇, 王鹏辉, 楚勇, 刘明明, 陈广怡, 陆银萍, 叶德泳   

  1. 复旦大学药学院药物化学教研室 上海 201203
  • 收稿日期:2011-09-03 修回日期:2012-03-08 发布日期:2012-03-23
  • 通讯作者: 叶德泳 E-mail:dyye@shmu.edu.cn
  • 基金资助:
    国家自然科学基金(No. 30672511)和创新药物平台(No. 2009ZX09301-011)资助项目.

Studies on Constructing of the Key Intermediate of Eudesmane Sesquiterpenoid Analogues via Diels-Alder Reaction

Zhang Yu, Wang Penghui, Chu Yong, Liu Mingming, Chen Guangyi, Lu Yinping, Ye Deyong   

  1. Department of Medicinal Chemistry, School of Pharmacy, Fudan University, Shanghai 201203
  • Received:2011-09-03 Revised:2012-03-08 Published:2012-03-23
  • Supported by:
    Project supported by the National Natural Science Foundation of China (No. 30672511) and the National Drug Innovation Program (No. 2009ZX09301-011).

以3-甲基-1,3-间苯二酚和异戊醛为原料分别合成亲双烯2-甲氧基-6-甲基对苯醌和双烯1-甲氧基-3-异丙基-1,3-丁二烯, 通过Diels-Alder 反应, 高区域选择性地得到桉烷类倍半萜骨架中间体2c.

关键词: Diels-Alder 反应, 桉烷, 倍半萜, 区域选择性

The key intermediate of eudesmane sesquiterpenoid analogue 2c was synthesized with high regioselectivity via Diels-Alder reaction from the dienophile 2-methoxyl-6-methyl-1,4-benzoquinone and the diene 1-methoxyl-3-isopropyl-1, 4-butadiene.

Key words: Diels-Alder reaction, eudesmane, sesquiterpenoid, regioselectivity