有机化学 ›› 2017, Vol. 37 ›› Issue (12): 3198-3203.DOI: 10.6023/cjoc201705041 上一篇    下一篇

研究论文

无金属催化的8-氨基喹啉C5位上的卤化反应

郝文燕, 王昱赟, 刘云云   

  1. 江西师范大学化学化工学院 南昌 330022
  • 收稿日期:2017-05-28 修回日期:2017-07-18 发布日期:2017-08-30
  • 通讯作者: 郝文燕 E-mail:wenyanhao@jxnu.edu.cn
  • 基金资助:

    国家自然科学基金(Nos.21562024,21762023)及江西省教育厅(No.GJJ160285)资助项目.

Catalyst-Free Selective C5-H Bromination and Chlorination of 8-Amido Quinolines

Hao Wenyan, Wang Yuyun, Liu Yunyun   

  1. College of Chemistry and Chemical Engineering, Jiangxi Normal University, Nanchang 330022
  • Received:2017-05-28 Revised:2017-07-18 Published:2017-08-30
  • Contact: 10.6023/cjoc201705041 E-mail:wenyanhao@jxnu.edu.cn
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos. 21562024, 21762023), and the Scientific Research Fund of Jiangxi Provincial Education Department (No. GJJ160285).

实现了无金属催化的8-氨基喹啉C5位的氧化C-H键卤化反应.该体系避免使用传统的金属催化剂以及化学当量的高价碘盐等作为氧化剂,在潮湿的空气中就能进行,使得本反应更具经济性和环境友好性.在该催化体系下反应底物显示出良好的官能团兼容性和反应性,并以高的区域选择性高产率地制备了C5卤代喹啉.

关键词: 8-氨基喹啉, 区域选择性, 无金属催化, C5-H键活化, 卤代反应

A simple and efficient selective halogenation (Cl, Br) reaction in the C5 position of 8-amidoquinolines has been developed via catalyst free C-H bond elaboration. This facile synthetic method shows good substrate tolerance and most of the halogenated products were obtained with excellent yield.

Key words: 8-amidoquinoline, selective, catalyst-free, C5-H bond, halogenation