有机化学 ›› 2018, Vol. 38 ›› Issue (7): 1849-1854.DOI: 10.6023/cjoc201711041 上一篇    下一篇

所属专题: 碳氢活化合辑2018-2019

研究简报

金属钯催化偶氮苯与Co(NO3)2·6H2O通过C-H活化邻位硝基化反应

王少凡a, 赵启鹏a, 王国栋b, 王凯b, 夏成才b   

  1. a 宁夏医科大学药学院 银川 750004;
    b 泰山医学院药学院 泰安 271016
  • 收稿日期:2017-11-22 修回日期:2018-01-28 发布日期:2018-03-08
  • 通讯作者: 夏成才 E-mail:xiachc@163.com
  • 基金资助:

    山东省医药卫生科技发展计划(No.2015WS0102)资助项目.

Palladium-Catalyzed Direct o-Nitrification of Azobenzenes with Co(NO3)2·6H2O via C-H Activation

Wang Shaofana, Zhao Qipenga, Wang Guodongb, Wang Kaib, Xia Chengcaib   

  1. a School of Pharmacy, Ningxia Medical University, Yinchuan 750004;
    b Pharmacy College, Taishan Medical University, Tai'an 271016
  • Received:2017-11-22 Revised:2018-01-28 Published:2018-03-08
  • Contact: 10.6023/cjoc201711041 E-mail:xiachc@163.com
  • Supported by:

    Project supported by the Projects of Medical and Health Technology Development Program in Shandong Province (No. 2015WS0102).

开发了一种通过钯催化C-H活化法将偶氮苯转化成邻硝基偶氮苯衍生物的有效合成方法,它是以廉价易得的六水合硝酸钴作为硝化源,以较高收率得到了多种o-硝基偶氮苯.

关键词: C-H活化, 偶氮苯, 硝酸钴, 硝化

An efficient protocol for conversion of azobenzenes into their ortho-nitro derivatives via palladium-catalyzed C-H bond activation has been developed. Commercially available and less expensive Co(NO3)2·6H2O was used as the nitrification reagent. Various o-nitroazobenzenes were obtained in excellent yields.

Key words: C-H activation, azobenzenes, Co(NO3)2·6H2O, nitrification