3-(噁唑-5-基)吲哚类天然产物生物活性及其衍生物的合成研究进展

doi:10.6023/cjoc201907047

有机化学 ›› 2020, Vol. 40 ›› Issue (2): 327-338.DOI: 10.6023/cjoc201907047 上一篇下一篇

综述与进展

3-(噁唑-5-基)吲哚类天然产物生物活性及其衍生物的合成研究进展

施展^a,b, 聂克睿^a, 刘畅^a, 张明智^a, 章维华^a

a 南京农业大学理学院南京 210095;
b 复旦大学化学系上海 200433

收稿日期:2019-07-28 修回日期:2019-10-03 发布日期:2019-11-07
通讯作者: 张明智, 章维华 E-mail:mzzhang@njau.edu.cn;zhwh@njau.edu.cn
基金资助:
国家自然科学基金（No.21602110）、重点研发计划（No.2018YFC1602804）、江苏省青年基金（No.BK20160734）和中央高校科研基本业务费（Nos.KYTZ201604，KYLH201908）资助项目.

Biological Activities of 3-(5-Oxazolyl)indole Natural Products and Advances on Synthesis of Its Derivatives

Shi Zhan^a,b, Nie Kerui^a, Liu Chang^a, Zhang Mingzhi^a, Zhang Weihua^a

a College of Sciences, Nanjing Agricutural University, Nanjing 210095;
b Department of Chemistry, Fudan University, Shanghai 200433

Received:2019-07-28 Revised:2019-10-03 Published:2019-11-07
Supported by:
Project supported by the National Natural Science Foundation of China (No. 21602110), the National Key R&D Program of China (No. 2018YFC1602804), the Jiangsu Provincial Science Foundation for Youths (No. BK20160734) and the Fundamental Research Funds for the Central Universities (Nos. KYTZ201604, KYLH201908).

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摘要/Abstract

3-（噁唑-5-基）吲哚类天然产物如Pimprinine，Streptochlorin等，广泛存在于海洋微生物中，因其具有多样的生物活性，在医药和农药领域中很有研究潜力.3-（噁唑-5-基）吲哚类天然产物的合成方法有很多研究报道，在吲哚结构上构建噁唑环是合成此类天然产物的关键.总结了已报道的3-（噁唑-5-基）吲哚类天然产物的生物活性，并对构建3-（噁唑-5-基）吲哚骨架的合成方法及部分主要反应机理进行了综述，探讨了3-（噁唑-5-基）吲哚类骨架作为一种优势活性结构在未来的应用前景.

关键词: 3-(噁唑-5-基)吲哚, 天然产物, 生物活性, 合成, 综述

3-(5-Oxazolyl)indole-type natural products such as pimprinine and streptochlorin, widely exist in marine microorganism, because of their diverse biological activity, 3-(5-oxazolyl)indoles show good research and development potential in the field of medicine and pesticide. Numerous studies have been performed to synthesize 3-(5-oxazolyl)indole-type natural products, in which the construction of indole ring and oxazole ring is the most important part. In this paper, the reported natural products with 3-(5-oxazolyl)indole skeleton structure and their biological activities are summarized, and the synthetic methods for 3-(5-oxazolyl)indole skeleton and some of their mechanism are also reviewed. The application prospect of 3-(5-oxazol-yl)indole as a dominant active structure in the future was discussed.

Key words: 3-(5-oxazolyl)indole, natural products, biological activities, synthesis, review

引用此文

施展, 聂克睿, 刘畅, 张明智, 章维华. 3-(噁唑-5-基)吲哚类天然产物生物活性及其衍生物的合成研究进展[J]. 有机化学, 2020, 40(2): 327-338.

Shi Zhan, Nie Kerui, Liu Chang, Zhang Mingzhi, Zhang Weihua. Biological Activities of 3-(5-Oxazolyl)indole Natural Products and Advances on Synthesis of Its Derivatives[J]. Chinese Journal of Organic Chemistry, 2020, 40(2): 327-338.

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3-(噁唑-5-基)吲哚类天然产物生物活性及其衍生物的合成研究进展

Biological Activities of 3-(5-Oxazolyl)indole Natural Products and Advances on Synthesis of Its Derivatives

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