有机化学 ›› 2020, Vol. 40 ›› Issue (6): 1697-1703.DOI: 10.6023/cjoc201912041 上一篇    下一篇

研究论文

O2参与下FeCl2催化的分子内氧化反应构建异噁唑杂环

阿布力米提·阿布都卡德尔, 汪荣, 买尔哈巴·买买提, 刘晨江   

  1. 新疆大学化学化工学院 乌鲁木齐 830046
  • 收稿日期:2019-12-18 修回日期:2020-02-05 发布日期:2020-03-04
  • 通讯作者: 阿布力米提·阿布都卡德尔, 刘晨江 E-mail:ablimit1970@126.com;pxylcj@126.com
  • 基金资助:
    国家自然科学基金(No.21562039)资助项目.

FeCl2-Catalyzed Intramolecular Aerobic Reaction for Construction of Isoxazoles Heterocycle

Abdukader Ablimit, Wang Rong, Mamat Marhaba, Liu Chenjiang   

  1. College of Chemical and Chemical Engineering, Xinjiang University, Urumqi 830046
  • Received:2019-12-18 Revised:2020-02-05 Published:2020-03-04
  • Supported by:
    Project supported by the National Natural Science Foundation of China (No. 21562039).

发展了一种廉价金属盐FeCl2催化氧气氧化下,高效、环保且简洁合成多取异噁唑衍生物的新方法.通过对金属盐来源和碱等反应条件的优化,确立了最佳的反应条件.在此反应条件下合成了19个新型多取代3,5-二芳基异噁唑衍生物,并成功培养了一个单晶,产率在80%~90%之间.经过1H NMR、13C NMR、元素分析及X单晶衍射确证了所得目标化合物的结构.

关键词: FeCl2催化, 氧气氧化, 异噁唑, 杂环, N—O键形成

A simple, practical and highly efficient synthesis of multi substituted isoxazole derivatives via cheap metal salt FeCl2-catalyzed direct aerobic oxidative has been developed. Nineteen novel multi-substituted 3,5-diaryl isoxazole derivtaves were synthesized and a single crystal was successfully cultivated. The products were get with about 70%~90% yields under mild conditions. The structures of products were fully characterized by 1H NMR, 13C NMR, elemental analysis and X-ray crystal.

Key words: iron catalysis, oxygen oxidation, isoxazole, heterocycle, N-O bond formation