光诱导N-芳基丙烯酰胺参与的吲哚酮合成研究进展

doi:10.6023/cjoc202407017

摘要/Abstract

吲哚酮骨架是一种非常有价值的结构单元,其合成研究具有重要意义。N-芳基丙烯酰胺类化合物反应活性好、廉价易得,是合成吲哚酮衍生物的重要原料。近年来光介导N-芳基丙烯酰胺参与的自由基环化反应取得了重要的研究进展,引起了广泛关注。本文系统综述了这一领域的最新研究进展,主要包括N-芳基丙烯酰胺与烷基自由基前体、含氟烷基自由基前体、酰基自由基前体、磺酰基自由基前体及其它类型自由基前体的自由基偶联环化反应等,讨论了这些光催化体系的优缺点、底物范围、反应机理等。

关键词: 吲哚酮, N-芳基丙烯酰胺, 自由基反应, 光介导

The oxindole scaffold is a highly valuable structural motif and their synthesis research is of great significance. N-arylacrylamides have been the important raw materials for the synthesis of oxindoles, because of their high reactivity, cheap and ready availability. In recent years, photo-mediated N-arylacrylamides engaged in radical cyclization reactions have made a great advance, which has received considerable attention. In this article, the research progress is systematically summarized, including radical coupling and cyclization reactions of N-arylacrylamides with alkyl, fluorinated alkyl, acyl, sulfonyl radical precursors, and among others. These methods bearing advantages and disadvantages, substrate scope, and mechanisms were discussed.

Key words: Oxindoles, N-arylacrylamides, radical reactions, photo- mediated

引用此文

谭永波, 舒洪波, 黄华文. 光诱导N-芳基丙烯酰胺参与的吲哚酮合成研究进展[J]. 有机化学, doi: 10.6023/cjoc202407017.

Tan Yongbo, Shu Hongbo, Huang Huawen. Recent advances in photo-induced oxindole formation from N-arylacrylamides[J]. Chinese Journal of Organic Chemistry, doi: 10.6023/cjoc202407017.

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