关键词: 2-芳基-2H-色烯, 手性合成, 手性金属配合物催化, 有机小分子催化, 研究进展

Chiral chromene structures are crucial components of numerous natural products and biologically active molecules. As a type of chromene, 2H-chromene is also an important representative of oxygen-containing heterocyclic compounds. It not only widely exists in natural products, pharmaceuticals, and bio-related molecules but also finds extensive applications in materials science and organic synthesis. Among them, chiral 2-aryl-2H-chromene derivatives not only exhibit broad pharmacological activities but also serve as key intermediates for the synthesis of many active natural products, thus holding significant research value in fields such as medicinal chemistry and synthetic chemistry. The enantiomers of chiral compounds or chiral drugs often exhibit distinct physiological activities in living organisms. Since the "The Thalidomide Tragedy", organic synthetic researchers have attached greater importance to chiral synthesis, and the use of pharmaceuticals with high optical purity has become a critical criterion in the pharmaceutical industry. Therefore, the research on chiral drugs is of great significance, and meanwhile, the synthesis of chiral compounds has also attracted considerable attention from synthetic researchers. This paper summarizes the research progress in the chiral synthesis of 2-aryl-2H-chromene compounds in recent years, mainly introducing three chiral synthesis methods for such chiral compounds, namely chemical resolution, kinetic resolution, and asymmetric catalysis involving chiral metal complexes or organosmall molecules. Additionally, the future development of this field is prospected.

Key words: 2-Aryl-2H-Chromene, Chiral Synthesis, Chiral Metal Complex Catalysis, Organic Small Molecule Catalysis, Research Progress