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封面介绍Recent advances in low-valent tungsten-catalyzed organic reactions are reviewed by Xu, Kong, Chen, Zhang, Ji, and Cheng on page 759. This review consolidates key developments in reaction design, mechanistic insights, and substrate scope expansion, positioning low-valent tungsten catalytic systems as a complementary and sus-tainable approach to conventional noble-metal systems -
封面介绍The recent advances in the chiral synthesis of 2-aryl-2H- chromenes are summarized by Zhou, Liu, Lei, Yang, and Jiang on page 773. It highlights three principal strategies, including chemical resolution, kinetic resolution, and asymmetric catalysis enabled by chiral metal complexes or small organic molecules. Future perspectives for the development of this research field are also presented. -
封面介绍A novel and efficient strategy for the synthesis of 2- hydroxy-indolin-3-ones through iodine-catalyzed intramolecular cyclization of N-(2-acetylphenyl)picolinade has been developed by He, Zhou, Jiang, Zhang, Wang, and Ma on page 961. This protocol features atom economy, metal-free, easy operation with cheap reagents, providing a useful and attractive route for the synthesis of 2-hydroxy-indolin-3-ones, which is widely presented in pharmaceuticals, biologically active molecules and natural products. -
封面介绍The one-pot chemoselective methylation of carboxylic acids using N-methyl-N-nitrosourea (MNU) as diazomethane precursor is reported by Liu, Sun, Chu and coworkers on page 907. By means of in situ generating and consuming diazomethane, the efficient methylation of carboxylic acids has been realized via Na2CO3 promotion in dioxane/H2O system, developing a safe and practical strategy for carboxylic acid methylation and phenyltetrazole N-methylation in pharmaceutical synthesis.
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本期栏目
综述与进展
研究论文
亮点述评