蕊木属生物碱arboridinine和arborisidine的全合成研究进展

doi:10.6023/cjoc202507021

综述与进展

蕊木属生物碱arboridinine和arborisidine的全合成研究进展

何卫刚^a,b,*, 段明月^a, 闫帅^a, 叶伟杰^a, 徐雪园^a, 孙先宇^a,*

^a苏州工学院生物与食品工程学院江苏常熟 215500;
^b中国药科大学药学院江苏南京 210009

收稿日期:2025-07-15 修回日期:2025-09-04
基金资助:
国家自然科学基金(No. 22401019)资助项目.

Progress in the Total Synthesis of the Kopsia Alkaloids Arboridinine and Arborisidine

He Weigang^a,b,*, Duan Mingyue^a, Yan Shuai^a, Ye Weijie^a, Xu Xueyuan^a, Sun Xianyu^a,*

^aSchool of Biology and Food Engineering, Suzhou University of Technology, Changshu, Jiangsu 215500;
^bSchool of Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu 210009

Received:2025-07-15 Revised:2025-09-04
Contact: *E-mail: heweigang@szut.edu.cn; sunxy@cslg.edu.cn
Supported by:
National Natural Science Foundation of China (No. 22401019).

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摘要/Abstract

吲哚生物碱分布广泛、结构复杂,并具有丰富的药理活性,是目前天然产物全合成领域的研究热点。生物碱arboridinine和arborisidine是从马来西亚的蕊木属植物中分离得到的,这两个生物碱特殊而高度复杂的笼状结构使其全合成研究极具挑战性,因此得到了广泛关注。本文总结了arboridinine和arborisidine目前的全合成研究进展,以期为相关天然产物的全合成提供参考。

关键词: 生物碱, 全合成, Arboridinine, Arborisidine

Indole alkaloids are widely distributed in nature and have rich pharmacological activities, so many indole alkaloids have emerged as hot targets for the total synthesis of natural products. The alkaloids arboridinine and arborisidine were isolated from a plant of the Kopsia genus found in Malaysia by Kam and co-workers in 2015 and 2016, respectively. These two pentacyclic monoterpenoid indole alkaloids have unique caged skeleton with multiple chiral centers. The highly complex cage structure of these alkaloids has brought great challenges to their total synthesis research. In addition, studies have found that arborisidine exhibits clear anti-gastric cancer activity when combined with pimelautide. The complex and attractive chemical structure and potential pharmacological activity, together with an extremely low natural abundance make their total synthesis research extremely attractive. Soon after the isolation, their total synthesis research has received extensive and sustained attention. Up to now, the total synthesis of arboridinine has be achieved by the research groups of Snyder, Ma, Zhai and Li, and the total synthesis of arborisidine by the groups of Snyder, Ma, Zhu, Jiao, She and Gao. This review summarizes the research progress of total synthesis of arboridinine and arborisidine, in order to provide reference for the total synthesis of the related natural products.

Key words: Alkaloids, Total synthesis, Arboridinine, Arborisidine

引用此文

何卫刚, 段明月, 闫帅, 叶伟杰, 徐雪园, 孙先宇. 蕊木属生物碱arboridinine和arborisidine的全合成研究进展[J]. 有机化学, doi: 10.6023/cjoc202507021.

He Weigang, Duan Mingyue, Yan Shuai, Ye Weijie, Xu Xueyuan, Sun Xianyu. Progress in the Total Synthesis of the Kopsia Alkaloids Arboridinine and Arborisidine[J]. Chinese Journal of Organic Chemistry, doi: 10.6023/cjoc202507021.

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