4,4′-联苯二酚合成方法研究进展

doi:10.6023/cjoc202606025

摘要/Abstract

4,4′-联苯二酚是合成先进聚合物、树脂及特种材料的关键基础原料,具有优异的热稳定性、化学耐受性和机械强度,可作为改性单体用于聚酯、聚氨酯、环氧树脂、液晶材料等领域,并在医药与农药合成中具有广泛应用. 该化合物结构中含有两个酚羟基,可发生取代、氧化等多种反应,衍生许多产物. 尽管4,4′-联苯二酚在多个行业中用途广泛,但目前高纯度(99.5%)产品仍全部依赖进口,合成面临重大挑战. 本文以合成4,4′-联苯二酚的原料为主线,系统梳理其多种合成路线,主要分为四类：以酚类化合物的氧化偶联、以联苯类化合物为骨架进行官能团转化、由4-羟基苯基衍生物构建联苯结构以及其他底物参与的方法,以期为高纯度4,4′-联苯二酚的合成研究提供参考.

关键词: 4,4'-联苯二酚, 氧化偶联, 还原消除, 合成方法

4,4′-Biphenol is a key basic raw material for the synthesis of advanced polymers, resins, and specialty materials. It possesses excellent thermal stability, chemical resistance, and mechanical strength, and can be used as a modifying monomer in polyesters, polyurethanes, epoxy resins, liquid crystal materials, as well as in the synthesis of pharmaceuticals and pesticides. The compound contains two phenolic hydroxyl groups in its structure, which can undergo various reactions such as substitution and oxidation, leading to many derivatives. Although 4,4′-biphenol is widely used across multiple industries, high-purity (99.5%) product is still entirely dependent on imports, and its synthesis faces significant challenges. This review takes the synthetic raw materials as the main thread and systematically summarizes various synthetic routes, which are mainly classified into four categories: oxidative coupling of phenolic compounds, functional group transformation using biphenyl compounds as the skeleton, construction of the biphenyl structure from 4-hydroxyphenyl derivatives, and methods involving other substrates, aiming to provide a reference for the synthesis research of high-purity 4,4′-biphenol.

Key words: 4,4'-Biphenol, oxidative coupling, reductive elimination, synthetic method

引用此文

张怀远, 王熙悦, 刘荣, 梁超荣, 张其国, 刘蓉蓉, 陈子玮, 梁茗钰. 4,4′-联苯二酚合成方法研究进展[J]. 有机化学, doi: 10.6023/cjoc202606025.

Zhang Huaiyuan, Wang Xiyue, Liu Rong, Liang Chaorong, Zhang Qiguo, Liu Rongrong, Chen Ziwei, Liang Mingyu. Recent Advances in the Synthesis of 4,4′-biphenol[J]. Chinese Journal of Organic Chemistry, doi: 10.6023/cjoc202606025.

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