有机化学 ›› 1991, Vol. 11 ›› Issue (3): 233-239. 上一篇    下一篇

研究论文

催化抗体

张礼和   

  1. 北京医科大学药学院
  • 发布日期:1991-06-25

Abzyme

ZHANG LIHE   

  • Published:1991-06-25

利用特异性的抗原产生的单克隆抗体具有催化很多有机化学反应的性质。特异性抗原可用适当的化学模型物与载体蛋白连接而成。设计化学模型物可考虑: (1)反应过滤态的稳定性; (2)反应基团的接近效应; (3)引入催化基团。

关键词: 催化, 有机化学, 反应机理, 化学反应, 生物化学, 单克隆抗体, 酶促, 抗体

A review with 16 refs., on catalytic antibodies (abzymes, monoclonal antibodies raised against specific haptens), discussing their preparation and application in the development of new artificial enzymes for use in chem., biol., and medicine. The generation of haptens from model chem. compounds and carrier proteins, especially designing of model chems. for the preparation of catalytic antibodies is also discussed.6

Key words: REACTION MECHANISM, CATALYSIS, CHEMICAL REACTION, ORGANIC CHEMISTRY, BIOCHEMISTRY, MONOCLONAL ANTIBODY, ENZYMATIC, ANTIBODY

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