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有机化学
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有机化学 ›› 1992, Vol. 12 ›› Issue (1): 58-61. 上一篇    下一篇

研究论文

5-(2,4-二氯苯氧亚甲基)-2-芳酰胺基-1,3,4-噻二唑的合成

张自义;林海霞   

  1. 兰州大学化学系
  • 发布日期:1992-02-25

Synthesis of 5[2,4-Dichlorophenoxymethylene)-2-aroylamino-1,3,4-thiadiazoles

ZHANG ZIYI;LIN HAIXIA   

  • Published:1992-02-25

研究了对1-(2,4-二氯苯氧乙酰基)-4-芳酰基氨基硫脲的酸催化环化, 它在酸催化下的环化是定向进行的, 环化途径是生成中间体后脱水而得到5-(2,4-二氯苯氧亚甲基)-2-芳酰胺基-1,3,4-噻二唑, 产物的结构经元素分析, 红外, 核磁以及质谱方法确证。

关键词: 催化, 酰胺 P, 苯氧基, 硫脲, 苯氧乙酸 P, 环化, 噻二唑

Thiadiazole derivatives [I; R = Ph, p-XC6H4 (wherein X = halo, NO2, Me, MeO), furyl, 2,4-Br2C6H3] are prepared by acid-catalyzed cyclization of thiosemicarbazide derivatives II. II (R = Ph) (1 mmol) in HOAc was refluxed 2-3 h to give 91.7% I (R = Ph). Use of H2SO4 for cyclization gave 64.0% yield.

Key words: PHENOXY GROUP, CATALYSIS, AMIDES P, THIOUREAS, PHENOXYACETIC ACID P, CYCLIZATION, THIADIAZOLE

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