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有机化学
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有机化学 ›› 1993, Vol. 13 ›› Issue (3): 250-252. 上一篇    下一篇

研究论文

1-芳酰基-3-(4-苯磺酰胺嘧啶)硫脲类化合物的合成

贾学顺;王玉炉;李用芳;何芳淑;单英方   

  1. 河南师范大学化学系;河南师范大学生物系
  • 发布日期:1993-06-25

Synthesis of 1-aroyl-3-(4-benzosulfonamidopyrimidine)-thioureas

JIA XUESHUN;WANG YULU;LI YONGFANG;HE FANGSHU;SHAN YINGFANG   

  • Published:1993-06-25

被引次数

8

研究了以无水乙腈为溶剂,通过芳酰异硫氰酸酯与磺胺嘧啶的加成反应合成12个新的1-芳酰基-3-(4-苯磺酰胺嘧啶)硫脲、生物测试指出化合物对大肠杆菌、枯草杆菌、变型杆菌有很强的抑制作用.此外,1-苯酰基-3-(4-苯磺酰胺嘧啶)硫脲和1-(P-氯代苯酰基 )-3-(4-苯磺酰胺嘧啶)硫脲对金黄色葡萄球菌也有很强的抑制作用.

关键词: 葡萄球菌属, 乙腈, 抗菌药, 异硫氰酸酯, 硫脲, 磺胺嘧啶, 枯草杆菌, 大肠杆菌, 加成反应

A series of new 1-aroyl-3-(4-benzosulfonamidopyrimidine)-thioureas I (R = H, Me, Br, Cl, iodo) were synthesized by the reaction of aroyl isothiocyanate with sulfadiazine in anhydrous acetonitrile. Preliminary biol. tests indicate that some of compounds I possess marked inhibiting activity against Bacillus coli, Bacillus subtilis, proteus, and Staphylococcus aureus at concentration of 10 ppm.

Key words: BACILLUS SUBTILIS, STAPHYLOCOCCIN, ACETONITRILE, ADDITION REACTION, THIOUREAS, SULFADIAZINE, ISOTHIOCYANATE, ESCHERICHIA COLI

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