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有机化学
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有机化学 ›› 2000, Vol. 20 ›› Issue (2): 251-254. 上一篇    下一篇

研究论文

利用四氯乙烷胺化反应合成联氢化嘧啶衍生物的研究

郭生;李增春;徐鸿章;姚丽   

  1. 内蒙古民族师院化学系
  • 发布日期:2000-04-25

Synthesis of bis - (hexahydropyrimidines) through reaction of diaminoalkanes with sym - tetrachloroethane

Guo Sheng;Li Zengchun;Xu Hongzhang;Yao Li   

  • Published:2000-04-25

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利用均四氯乙及二氯甲烷的胺化反应，合成了联氢化嘧啶衍生物1～5，4a,8b-反-4,5,8a,9a-四氮杂全氢芴(6)和8b,8c-顺-3a,4a,7a,8a-四氮杂环戊并全氢芴(7)。化合物(6)和(7)的顺反异构体在酸催化下开环，异构生成较稳定的6b和7a。

关键词: 四氯乙烷, 胺化, 嘧啶P, 异构体, 二氯甲烷

1,3 - diaminoalkanes react with sym - tetrachloroethane to give crystaline 2,2' -bis- (hexahydropyrimidine) derivatives 1～5, after treatment with aqua ammonia. Subsequently 1 was treated with different amounts of dichloromethane to give higher yields of 4a, 8b - trans - perhydro - 4, 5, 8a, 9a - tetraazafluorene (6) and 8b, 8c - cis - perhydro - 3a, 4a, 7a,I 8a -tetrazacyclopentanofluorene (7), The transormation mechanisms for cis - and trans - 6 and 7 are proposed.

Key words: CELLON (= TETRACHLOROETHANE), AMINATE, PYRIMIDINE P, ISOMER, DICHLOROMETHANE

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