关键词: 蛋白质, 肽, 聚乙二醇, 化学修饰

The pegylated proteins and peptides have found promising applications in biotechnological and biomedical fields due to the improved solubility, thermal and mechanical stability, reduced antigenicity and immunogenicity, enhanced circulating half-lives, optimized pharmacokinetic and pharmacodynamic properties. Consequently, pegylation gradually becomes a platform technology. The importance of chemistry of protein and peptide pegylation has attracted more and more attentions as more PEG-conjugates have reached late phase clinical trials. In this paper, the first-generation and second- generation pegylation chemistry is briefly reviewed, mainly including the different types of PEG chemical modifiers and their performance comparison.

Key words: PROTEIN, PEPTIDE, POLYGLYCOL, CHEMICLAL MODIFICATION