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有机化学 ›› 2004, Vol. 24 ›› Issue (10): 1284-1287. 上一篇    下一篇

研究简报

不饱和烯酸酰基硫脲化合物的合成与抑菌活性测定

何湘琼, 唐文明*, 宋宝安, 胡德禹, 逄丽丽, 桑维钧, 杨松, 金林红   

  1. 贵州大学精细化工研究开发中心 贵阳 550025
  • 收稿日期:2003-08-12 修回日期:2004-01-13 接受日期:2004-04-27 发布日期:2022-09-20
  • 基金资助:
    国家重点基础研究发展规划(“973”计划,No. 2003CB114404)和国家自然科学基金(No.20162001)资助项目.

Synthesis and Fungicidal Activity of Unsaturated Acyl Thiourea of N-Heterocycle

HE Xiang-Qiong, TANG Wen-Ming*, SONG Bao-An, HU De-Yu, PANG Li-Li, SANG Wei-Jun, YANG Song, JIN Lin-Hong   

  1. Research and Development Center of Fine Chemicals, Guizhou University, Guiyang 550025
  • Received:2003-08-12 Revised:2004-01-13 Accepted:2004-04-27 Published:2022-09-20
  • Contact: * E-mail: sdkyc@163.net

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采用山梨酸和肉桂酸为先导化合物,经过酰氯化和硫脲化,引入活性的环状化合物,合成了6个新化合物,经核磁共振氢谱、红外光谱和元素分析测定,确认了新化合物的结构.在此基础上对目标化合物进行了防治辣椒枯萎病菌、小麦赤霉病菌、马铃薯晚疫病菌的生物活性测试.结果表明,部分化合物有一定的抑菌活性.

关键词: 山梨酸, 杂环, 酰基硫脲, 合成, 抑菌活性

Six new heterocyclic thiourea derivatives were synthesised byacylchlorination and then thioureation of the sorbic acid and cinnamic acid. Their structures were confirmed by 1H NMR and IR spectra and elemental analysis. Their biological activity testing was carried out. The results of bioassayshow that some compounds have fungicidal activities.

Key words: sorbic acid, heterocycle, acyl thiourea, synthesis,fungicidal activity