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有机化学
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有机化学 ›› 2004, Vol. 24 ›› Issue (3): 334-337. 上一篇    下一篇

研究简报

微波作用下1,5-苯并硫氮杂䓬-α-溴代-β-内酰胺衍生物的合成

张萍, 李文红, 李媛*   

  1. 河北师范大学化学系 石家庄 050016
  • 收稿日期:2003-07-17 修回日期:2003-09-19 接受日期:2003-10-08 发布日期:2022-09-20

Synthesis of α-Bromo-β-lactam Derivatives of 1,5-Benzothiazepines under Microwave Irradition

ZHANG, Ping, LI, Wen-Hong, LI, Yuan*   

  1. Department of Chemistry, Hebei Normal University, Shijiazhuang 050016
  • Received:2003-07-17 Revised:2003-09-19 Accepted:2003-10-08 Published:2022-09-20
  • Contact: *E-mail: lgchen@tju.edu.cn; Tel & Fax: 022-27406314.

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1,5-苯并硫氮杂鉮、溴乙酰氯在三乙胺的存在下,用微波辐射合成了5个新的1,5-苯并硫氮杂鉮-α-溴代-β-内酰胺衍生物,并且还合成了已用常规方法合成出的9个1,5-苯并硫氮杂鉮-β-内酰胺衍生物,对其结构进行了表征.文中研究了微波促进这类反应的最佳反应条件.

关键词: 1,5-苯并硫氮杂鉮, β-内酰胺, 微波辐射

Five new α-bromo-β-lactam derivatives of 1,5-benzothiazepines were synthesized by the reaction of 1,5-benzothiazepines with bromoacetyl chloride under microwave irradiation. Nine β-lactam derivatives were also synthesized which had been obtained under routine method. Their structures were confirmed by 1H NMR, IR, MS, and elemental analysis. The optimal conditions of this kind of reaction were studied.

Key words: 1,5-benzothiazepine, β-lactam, microwave irradiation