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有机化学
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有机化学 ›› 2005, Vol. 25 ›› Issue (08): 902-912. 上一篇    下一篇

综述与进展

奥利司他的全合成研究进展

杨小波，陈再新*，张奕华*   

  1. (1中国药科大学新药研究中心 南京 210009)
    (2江苏亚邦药物研发有限公司 南京 210024)
  • 收稿日期:2004-07-05 修回日期:2004-12-16 发布日期:2005-07-30
  • 通讯作者: 陈再新，张奕华

Progress in Total Synthesis of Orlistat

YANG Xiao-Bo,CHEN Zai-Xin*,ZHANG Yi-Hua*   

  1. (1 Center of Drug Discovery, China Pharmaceutical University, Nanjing 210009)
    (2 Jiangsu Yabang Pharmaceutical Research & Development Company, Ltd, Nanjing 210024)
  • Received:2004-07-05 Revised:2004-12-16 Published:2005-07-30
  • Contact: CHEN Zai-Xin, ZHANG Yi-Hua

PDF

4044

被引次数

7

综述了减肥药物奥利司他的全合成的研究进展. 根据合成策略上的不同, 将全合成研究分三部分进行了概述.

关键词: 奥利司他, tetrahydrolipstatin, 全合成, 减肥药物

A brief historical survey and recent development in total synthesis of orlistat, which is widely used as anti-obesity drug in clinic, were reviewed. The total synthesis methods were summarized in three parts on the basis of the synthetic strategies.

Key words: total synthesis, orlistat, tetrahydrolipstatin, anti-obesity drug