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有机化学
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有机化学 ›› 2005, Vol. 25 ›› Issue (9): 1094-1099. 上一篇    下一篇

研究论文

天然产物(－)-Patriscabrol和(＋)-Isopatriscabrol的全合成研究

谢平*，焦晓臻，陈淑凤，梁晓天   

  1. (中国协和医科大学 中国医学科学院药物研究所 北京 100050)
  • 收稿日期:2004-11-09 修回日期:2005-04-30 发布日期:2005-08-24
  • 通讯作者: 谢平

Study of Synthesis of Natural Product (－)-Patriscabrol and (＋)-Isopatriscabrol

XIE Ping*,JIAO Xiao-Zhen,CHEN Shu-Feng,LIANG Xiao-Tian   

  1. (Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050)
  • Received:2004-11-09 Revised:2005-04-30 Published:2005-08-24
  • Contact: XIE Ping

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以反丁烯二酰氯和薄荷醇为起始原料, 经十四步反应, 得到光活的(－)-patriscabrol和(＋)-isopatriscabrol, 总收率约为4.6%. 化合物的结构经1H NMR, MS, NOE差谱, HMBC, HMQC确定.

关键词: 粗叶败酱, 全合成, (＋)-isopatriscabrol, (－)-patriscabrol

(－)-Patriscabrol and (＋)-isopatriscabrol have been synthesized via fumaryl chloride and L-menthol as starting material in fourteen steps with the total yield about 4.6%. The structures of the products were confirmed by 1H NMR, MS, NOE, HMBC and HMQC spectra.

Key words: (＋)-isopatriscabrol, total synthesis, (－)-patriscabrol, Patrinia Scabra