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有机化学
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有机化学 ›› 2006, Vol. 26 ›› Issue (02): 219-222. 上一篇    下一篇

研究论文

2-氰基-2,3,3-三甲基-5-硫代-吡咯烷的合成新法

胡炳成*，吕春绪，蔡超君   

  1. (南京理工大学化工学院 南京 210094)
  • 收稿日期:2005-04-04 修回日期:2005-08-29 发布日期:2006-01-21
  • 通讯作者: 胡炳成

A Novel Method for Synthesis of 2-Cyano-2,3,3-trimethyl-5- thi-oxopyrrolidine

HU Bing-Cheng*,LÜ Chun-Xu,CAI Chao-Jun   

  1. (School of Chemical Engineering, Nanjing University of Science & Technology, Nanjing 210094)
  • Received:2005-04-04 Revised:2005-08-29 Published:2006-01-21
  • Contact: HU Bing-Cheng

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被引次数

5

以3,3-二甲基-4-戊烯酸甲酯为原料, 经过6步反应合成了目标产物2-氰基-2,3,3-三甲基-5-硫酮-吡咯烷, 反应的总收率约为37%, 其中关键步骤为分子内环化和碘化氢消除反应. 通过元素分析, 1H NMR, IR和MS对所合成化合物的结构进行了表征.

关键词: 氰基三甲基硫酮吡咯烷, 二甲基戊烯酸甲酯, 环化反应, 消除反应

2-Cyano-2,3,3-trimethyl-5-thioxopyrrolidine was efficiently synthesized in a total yield of 37% from methyl 3,3-dimethyl-4-pentenate via six steps, including an intramolecular cyclization and an elimination of hydrogen iodide as key steps. All compounds were characterized by elemental analysis, 1H NMR, IR and MS spectra.

Key words: methyl dimethylpentenate, cyclization, elimination, cyanotrimethyl thioxopyrrolidine