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有机化学
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有机化学 ›› 2007, Vol. 27 ›› Issue (02): 209-217. 上一篇    下一篇

综述与进展

氧化酶及烷烃氧化

姜标a，伍登熙b，左亚军b，郜莉b，李祖义*,a   

  1. (a中国科学院上海有机化学研究所 上海 200032)
    (b上海华谊集团公司 上海 200025)
  • 收稿日期:2006-06-05 修回日期:2006-08-31 发布日期:2007-01-30
  • 通讯作者: 李祖义

Oxygenases and Oxygenation of Alkanes

JIANG Biaoa, WU Deng-Xib, ZUO Ya-Junb, GAO Lib, LI Zu-Yi*,a   

  1. (a Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032)
    (b Shanghai Huayi Company, Shanghai 200025)
  • Received:2006-06-05 Revised:2006-08-31 Published:2007-01-30
  • Contact: LI Zu-Yi

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记述了氧化酶在生物催化中的应用. 较之传统的化学反应, 氧化还原生物催化反应有较好的选择性、可控性和经济性, 人们正在积极地寻找这类催化剂. 自然界中被高度还原的烃类品种丰富, 因此催化烷烃末端或近末端氧合反应的酶也相对容易找到. 很多这一类的酶生化特性已作了详细的描述, 烷烃加氧酶催化高附加值反应的潜力已得到了广泛地认可.

关键词: 氧化酶, 烷烃, 羟化酶

This article describes oxidising enzymes used for biocatalytic applications. Redox biocatalysts are highly sought after because of the selectivity, controllability and economy of their reactions, in comparison with conventional chemical reactions. As highly reduced hydrocarbons are abundant in the environment, enzymes that catalyze the terminal or subterminal oxygenation of alkanes are relatively easy to find. A number of these enzymes have been biochemically characterized in detail, because the potential of alkane hydroxylases to catalyze high added-value reactions was widely recognized.

Key words: alkane, hydroxylase, oxygenase