SIOC English
有机化学
高级检索

有机化学 ›› 2007, Vol. 27 ›› Issue (11): 1345-1351. 上一篇    下一篇

综述与进展

非酶催化动力学拆分的研究进展

苏宁，张方林，龚跃法*   

  1. (华中科技大学化学系 武汉 430074)
  • 收稿日期:2006-05-08 修回日期:2006-08-11 发布日期:2007-10-20
  • 通讯作者: 龚跃法

Recent Advances in Kinetic Resolution UsingNon-Enzymatic Catalysts

SU Ning,ZHANG Fang-Lin,GONG Yue-Fa*   

  1. (Department of Chemistry, Huazhong University of Science and Technology, Wuhan 430074)
  • Received:2006-05-08 Revised:2006-08-11 Published:2007-10-20
  • Contact: GONG Yue-Fa

PDF

1348

被引次数

4

动力学拆分是合成光学纯化合物的重要方法之一. 在酶催化的动力学拆分取得进展的同时, 近几年有关非酶催化的动力学拆分正在成为人们研究的热点, 主要拆分反应涉及对映选择性的酰化、氧化、还原、开环、成环、取代和加成等反应, 对该领域的最新研究进展进行了简要综述.

关键词: 动力学拆分, 非酶催化, 酰化, 开环成环, 氧化还原

Kinetic resolution is one of the important synthetic methods to produce optically pure compounds. While a great progress was achieved in the domain of enzymatic kinetic resolution during the past years, non-enzymatic kinetic resolution is becoming another current hot area, which mainly refers to enanti-oselective acylation, oxidation, reduction, ring-opening, ring-closing, substitution and addition, etc. Recent advances in this field are briefly reviewed.

Key words: non-enzymatic catalysis, acylation, oxidation and reduction, ring opening and closing, kinetic resolution