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有机化学
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有机化学 ›› 2007, Vol. 27 ›› Issue (12): 1577-1581. 上一篇    下一篇

研究简报

在离子液体中6-羟基-2(1H)喹啉酮的合成及反应性研究

孙莉，孙会，吕雪皓，李东伟
郑人华，邓琼，裴文*   

  1. (浙江工业大学化学工程与材料学院 杭州 310014)
  • 收稿日期:2007-01-24 修回日期:2007-04-27 发布日期:2007-12-04
  • 通讯作者: 裴文

Synthesis and Reactions of 6-Hydroxy-2(1H)-quinolin-2-one inIonic Liquid

SUN Li, SUN Hui, LÜ Xue-Hao, LI Dong-Wei
ZHENG Ren-Hua, DENG Qiong, PEI Wen*   

  1. (College of Chemical Engineering and Materials, Zhejiang University of Technology, Hangzhou 310014)
  • Received:2007-01-24 Revised:2007-04-27 Published:2007-12-04
  • Contact: PEI Wen

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1332

被引次数

5

6-羟基-2(1H)-喹啉酮是心血管和降压药物的重要中间体. 设计合成了一种在[Bmim]AlCl4离子液体中合成6-羟基-2-(1H)-喹啉酮的新方法; 研究了离子液体中6-羟基-2(1H)-喹啉酮母体环上羰基、氨基和不饱和键部位的化学反应. 此法后处理简便, 收率高, 是一种环境友好的绿色化学合成技术.

关键词: 6-羟基-2-(1H)-喹啉酮, 离子液体, 新合成方法, 绿色化学合成技术, 反应

6-Hydroxy-2(1H)-quinolin-2-one is an important pharmaceutical intermediate for antihypertension and cardiovascular drugs. It could be synthesized in the ionic liquid of [Bmim]AlCl4 and its esterification and allylation might occur with chloroformate or allyl chlorides in [Bmim][BF4]. The new procedure for preparing 6-hydroxy-2(1H)-quinolin-2-one has the advantages of good yield, simple operation and environmental benignity.

Key words: ionic liquid, green chemistry, new synthetic method, reaction, 6-hydroxy-2(1H)-quinolinone