有机化学 ›› 2008, Vol. 28 ›› Issue (03): 515-520. 上一篇    下一篇

研究简报

FeCl3催化羰基化合物的还原卤代反应

盛春荠,李志芳,杨成军,来国桥*,邱化玉   

  1. (杭州师范大学有机硅化学及材料技术教育部重点实验室 杭州 310012)
  • 收稿日期:2007-01-10 修回日期:2007-09-13 发布日期:2008-03-18
  • 通讯作者: 来国桥

Ferric Chloride-Catalyzed Deoxygenative Halogenation of Carbonyl Compounds

SHENG Chun-Qi,LI Zhi-Fang,YANG Cheng-Jun,LAI Guo-Qiao*,QIU Hua-Yu   

  1. (Key Laboratory of Organosilicon Chemistry and Material Technology, Ministry of Education,
    Hangzhou Normal University, Hangzhou 310012)
  • Received:2007-01-10 Revised:2007-09-13 Published:2008-03-18
  • Contact: LAI Guo-Qiao

在甲基二氯硅烷作用下, FeCl3能催化羰基化合物(醛、酮)的还原氯代反应, 得到相应的氯代产物; 在甲基二氯硅烷、PBr3或NaI作用下, FeCl3可以催化羰基化合物(醛、酮)的还原溴代或碘代反应, 分别以良好的收率得到相应的溴代烷或碘代烷.

关键词: 三氯化铁, 还原卤代, 羰基化合物, 甲基二氯硅烷

Ferric chloride catalyzed direct conversion of carbonyl compounds to the corresponding chloride with silicon hydride (dichloromethylsilane, chlorodiphenylsilane or trichlorosilane) was realized. In the presence of PBr3 or NaI, ferric chloride-catalyzed deoxygenative halogenation of carbonyl compounds also took place smoothly to give the corresponding bromide or iodide in moderate to good yields.

Key words: reductive halogenation, carbonyl compound, FeCl3, dichloromethylsilane